A new option may be coming as soon as October
If you suffer from nasal polyps, you know how frustrating the symptoms can be—blocked nose, loss of smell, constant congestion, and sometimes the need for repeat surgeries. But there’s good news: a new medication called Tezspire (tezepelumab) may soon be approved by the FDA to treat nasal polyps, possibly as early as October 2025.
What is Tezspire?
Tezspire is a type of medicine called a biologic. It’s already FDA-approved to treat severe asthma. Now, researchers are studying it for people with chronic rhinosinusitis with nasal polyps (CRSwNP).
Biologics are different from standard medications like steroid sprays or pills. They target the underlying inflammation in the body that causes polyps to grow, rather than just masking the symptoms.
How Does It Work?
Tezspire blocks a molecule called TSLP. You can think of TSLP as a “master switch” that turns on inflammation in the nose and sinuses. By turning off this switch, Tezspire helps calm the inflammation that makes polyps grow and cause symptoms.
What Does the Research Show?
A recent clinical trial looked at people with nasal polyps who used Tezspire compared to those who got a placebo (dummy shot). After one year:
- Polyp size got smaller in many patients.
- Nasal congestion improved—patients could breathe better.
- Sense of smell improved for many.
- Fewer people needed surgery (almost none in the Tezspire group compared to about 1 in 5 in the placebo group).
- Less need for steroid pills, which often have side effects.
Doctors running the study say these results are very promising and could change how nasal polyps are treated in the future.
When Could It Be Approved?
The FDA has not officially approved Tezspire for nasal polyps yet, but based on the strong research results, experts believe a decision could come as early as October 2025.
What This Means for Patients
If you’ve been struggling with nasal polyps—especially if you’ve needed surgery more than once or rely on steroid pills—Tezspire may soon become another option to discuss with your doctor.
It’s not available for nasal polyps just yet, but the team at NY Allergy & Sinus Centers will keep patients updated as soon as approval happens.
Frequently Asked Questions About Tezspire
Q: How is Tezspire given?
A: Tezspire is given as a shot under the skin (similar to an insulin shot) once every 4 weeks. Most patients can do this at home after training.
Q: Is Tezspire safe?
A: In studies so far, Tezspire has been well tolerated. The most common side effects are mild, such as sore throat, injection site reactions, or joint pain. Serious side effects are rare, but as with any biologic, allergic reactions are possible.
Q: How is Tezspire different from Dupixent?
A: Both Tezspire and Dupixent are biologic medicines used for nasal polyps. The main difference is how they work:
- Dupixent blocks specific inflammation pathways (IL-4 and IL-13).
- Tezspire works earlier in the process, blocking a “master switch” of inflammation (TSLP).
This may make Tezspire helpful for a broader group of patients.
Q: Will Tezspire replace surgery for nasal polyps?
A: Not always—but it may greatly reduce the need for surgery. In the recent study, almost none of the patients on Tezspire needed surgery during the year, compared to about 1 in 5 of those not on the drug.
Q: When will Tezspire be available for nasal polyps?
A: It’s not approved yet, but the FDA may decide as soon as October 2025. Once approved, doctors can start prescribing it for patients with nasal polyps.
Q: How do I know if I’m a candidate for Tezspire?
A: If you have chronic sinus symptoms with polyps, especially if you’ve already tried sprays, pills, or surgery, Tezspire may be an option once approved. The best way to find out is to talk to an allergy or sinus specialist.
Stay Updated and Get Expert Care
At NY Allergy & Sinus Centers, we stay at the forefront of new treatments for nasal polyps, including upcoming options like Tezspire.
If you’re struggling with chronic nasal polyps, repeat sinus infections, or loss of smell, our trained allergists and sinus specialists can help. We’ll keep you informed as soon as Tezspire becomes FDA-approved.
With convenient offices across New York City and Long Island, it’s easy to find a location near you. See all our locations here »
Schedule a consultation today to discuss your symptoms and learn about current and upcoming treatment options for nasal polyps.