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#1 Intradermal Testing in NYC

Intradermal Testing

A highly sensitive allergy test that detects specific IgE antibodies by injecting a small amount of allergen under the skin—especially effective for insect sting allergies.
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Intradermal Testing
  • More sensitive than skin prick
  • Covered by insurance
  • Same-day results available

What to Expect with Intradermal Testing

1

Book an appointment

Schedule a visit at one of our convenient NYC locations. Your allergist will review your symptom history and determine whether intradermal testing is appropriate for your situation—especially if a prior skin prick test was negative but allergy is still suspected.

2

Complete a test

A small amount of allergen is injected just below the skin’s surface using a fine needle, forming a small bubble. The area is observed for 20–30 minutes. A positive reaction will cause redness and slight swelling at the injection site. The procedure is well-tolerated and performed in-office by your allergist.
3

Customized treatment plan

Your provider will review your results immediately. If an allergy is confirmed, they will outline a personalized treatment plan—which may include avoidance strategies or immunotherapy—tailored specifically to your test findings.

What is Intradermal Testing?

Intradermal allergy testing is another skin testing method used to determine whether an individual is allergic to a specific allergen. It is similar to skin prick testing, with one key difference: a small amount of the suspected allergen is injected just beneath the skin’s surface using a fine needle.

After about 20 minutes, the injection site is examined for a reaction. A typical positive reaction appears as a small raised hive (called a wheal) with surrounding redness and mild swelling. This response indicates the presence of specific IgE antibodies—the antibodies involved in allergic reactions.

Intradermal testing is more sensitive than skin prick testing and is most commonly used to evaluate insect sting allergies or when a skin prick test is negative but an allergy is still strongly suspected.

Advantages of Intradermal Testing

Intradermal testing offers important benefits, particularly when greater sensitivity is needed to reach an accurate diagnosis.
Higher Sensitivity Than Skin Prick Testing
Because allergen is injected beneath the skin rather than just scratched onto the surface, intradermal testing detects weaker allergic responses that skin prick tests may miss. This makes it especially valuable for confirming suspected allergies that returned negative on a prior test.
Intradermal testing delivers a standardized dose of allergen under the skin, reducing variability and improving the consistency of results compared to surface-level testing methods.
Intradermal testing is the preferred method for evaluating insect venom allergies (such as bee or wasp stings), where accurate identification is critical to preventing potentially life-threatening reactions.
All intradermal testing is performed in our clinic under direct allergist supervision, with allergy medications on hand to manage any reactions quickly and safely.

How to Prepare For Intradermal Testing

To ensure the most accurate results, your allergist will ask you to stop taking antihistamines and certain other medications five to seven days before your intradermal test. These medications can suppress the immune response and lead to false-negative results. Inform your provider about all medications you are currently taking—including prescription drugs, over-the-counter medications, herbal supplements, and vitamins—so they can advise you on what to temporarily pause before the test. Avoid applying creams or lotions to the area being tested on the day of your appointment. Wear comfortable clothing that allows easy access to your upper arm, where the test is typically performed.

Intradermal Testing Frequently Asked Questions

What is the difference between intradermal testing and skin prick testing?

In skin prick testing, the allergen is placed on the surface of the skin, which is then lightly pricked. In intradermal testing, the allergen is injected directly under the skin. Intradermal testing is more sensitive and is typically used when a skin prick test is negative but allergy is still clinically suspected.

Does intradermal testing hurt?

The injection involves a very fine needle and is generally well-tolerated. Most patients describe it as a mild pinch. If you test positive, you may experience itching or mild swelling at the site, which typically resolves within 20–30 minutes.

Why would my allergist recommend intradermal testing instead of a skin prick test?

Your allergist may recommend intradermal testing if your skin prick test came back negative but they still strongly suspect you have an allergy based on your symptoms and history. It is also the preferred test for evaluating insect sting allergies due to its higher sensitivity.

Is intradermal testing safe?

Yes. All intradermal testing is performed in our office under allergist supervision. Emergency allergy medications are always available in the event of a strong reaction. The test is considered safe when performed by a board-certified allergist in a clinical setting.

How long does the intradermal test take?

The test itself takes only a few minutes to administer. You will then wait 20–30 minutes in the office while your allergist monitors the injection sites for any reaction. Your results will be reviewed with you the same day.

Can I take my medications before the intradermal test?

Certain medications, particularly antihistamines, can interfere with intradermal testing and should be stopped five to seven days before the test. Your allergist will provide specific instructions based on your current medication regimen. Do not stop any prescription medications without first consulting your provider.

Can children undergo intradermal testing?

Intradermal testing can be performed on older children and teenagers, though it is generally reserved for cases where a skin prick test has already been completed. Your allergist will assess whether the test is appropriate for your child based on their age, symptoms, and medical history.